Best Bets for NCAA Basketball Picks Against the Spread for Saturday, February 22
Published 6:22 pm Friday, February 21, 2025
The Saturday college basketball slate has plenty of exciting matchups in store. Our computer model has suggested picks against the spread for 10 games, among them the Iowa State Cyclones taking on the Houston Cougars.
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Today’s NCAA Men’s Basketball Picks ATS
ATS Pick: Iowa State +12.5 vs. Houston
- Matchup: Iowa State Cyclones at Houston Cougars
- Time: 2 p.m. ET
- Date: February 22
- Computer Projection: Houston by 6.7 points (Bet now on BetMGM)
- Spread: Houston (-12.5)
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: LIU +1.5 vs. Le Moyne
- Matchup: Long Island Sharks at Le Moyne Dolphins
- Time: 4 p.m. ET
- Date: February 22
- Computer Projection: LIU by 3.3 points (Bet now on BetMGM)
- Spread: Le Moyne (-1.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Nicholls State -3.5 vs. UT Rio Grande Valley
- Matchup: UT Rio Grande Valley Vaqueros at Nicholls State Colonels
- Time: 4 p.m. ET
- Date: February 22
- Computer Projection: Nicholls State by 8.1 points (Bet now on BetMGM)
- Spread: Nicholls State (-3.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Saint Francis (PA) +1.5 vs. Fairleigh Dickinson
- Matchup: Fairleigh Dickinson Knights at Saint Francis (PA) Red Flash
- Time: 2 p.m. ET
- Date: February 22
- Computer Projection: Saint Francis (PA) by 2.9 points (Bet now on BetMGM)
- Spread: Fairleigh Dickinson (-1.5)
- TV Channel: NEC Front Row
ATS Pick: Mississippi Valley State +23.5 vs. Texas Southern
- Matchup: Mississippi Valley State Delta Devils at Texas Southern Tigers
- Time: 6 p.m. ET
- Date: February 22
- Computer Projection: Texas Southern by 19.4 points (Bet now on BetMGM)
- Spread: Texas Southern (-23.5)
- TV Channel: SWAC Digital Network
Bet on this or any men’s college basketball matchup at BetMGM.
ATS Pick: Cal Baptist +9.5 vs. Grand Canyon
- Matchup: Cal Baptist Lancers at Grand Canyon Antelopes
- Time: 8 p.m. ET
- Date: February 22
- Computer Projection: Grand Canyon by 5.6 points (Bet now on BetMGM)
- Spread: Grand Canyon (-9.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Ole Miss +1.5 vs. Vanderbilt
- Matchup: Ole Miss Rebels at Vanderbilt Commodores
- Time: 3:30 p.m. ET
- Date: February 22
- Computer Projection: Ole Miss by 2.2 points (Bet now on BetMGM)
- Spread: Vanderbilt (-1.5)
- TV Channel: SEC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: American -3.5 vs. Boston University
- Matchup: Boston University Terriers at American Eagles
- Time: 4 p.m. ET
- Date: February 22
- Computer Projection: American by 7.1 points (Bet now on BetMGM)
- Spread: American (-3.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Kentucky +9.5 vs. Alabama
- Matchup: Kentucky Wildcats at Alabama Crimson Tide
- Time: 6 p.m. ET
- Date: February 22
- Computer Projection: Alabama by 5.9 points (Bet now on BetMGM)
- Spread: Alabama (-9.5)
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: McNeese -10.5 vs. Texas A&M-CC
- Matchup: Texas A&M-CC Islanders at McNeese Cowboys
- Time: 5 p.m. ET
- Date: February 22
- Computer Projection: McNeese by 14 points (Bet now on BetMGM)
- Spread: McNeese (-10.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
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